4-Nitroquinoline 1-Oxide에 대한 유산균의 항돌연변이 효과

Antimutagenicity of the Cell Extracts of Lactic Acid Bacteria against 4-Nitroquinoline 1-Oxide

Intestinal lactic acid bacteria (LAB) for humans are closely associated to the host’s health because the presence of LAB is an important bio-defense factor in preventing colonization and subsequent proliferation of pathogenic bacteria in the intestine. Some probiotics such as Lactobacillus species can intoxication of carcinogens including chemical mutagens. The purpose of this study was to compare the ability of antimutagenesity among 24 strains of LAB isolated from infant feces, yogurt and kimchi etc. The antimutagenic effects of protein fractions extracted from the cells of 24 LAB strains were investigated using mutagens as 4-nitroquinoline-N -oxide in Ames test (Salmonella Typhimurium TA 100). In the Ames test, dose-dependent activity was exhibited significantly against 4NQO. Three strains of Lactobacillus showed the highest anti-4NQO activitiy (62.1%) among the tested strains of LAB.