상세검색
최근 검색어 전체 삭제
다국어입력
즐겨찾기0
162809.jpg
KCI등재후보 학술저널

Ginsenoside 대사에서 장내미생물의 역할과 유산균을 활용한 생물전환

The Role of Gut Microbiota in Ginsenoside Metabolism and Biotransformation of Ginsenoside by Lactic Acid Bacteria

Ginseng, the root of the Panax ginseng, has been widely used as a traditional herbal medicine in Korea, China, and Japan for thousands of years. Now ginseng has become popular as functional health food and natural medicine and it is one of the bestselling natural products in the world. Gut microbiota has been found to play an important role in the metabolism and pharmacological action of orally administered ginseng. Recent animal and clinical studies have shown that compound K (20-O -beta-D-glucopyranosyl-20(S)-protopanaxadiol, CK) is the major ginsenoside metabolite deriving from gut microbiota-induced biotransformation and is more efficiently absorbed into the systemic circulation than its parent ginsenosides. Since ginsenoside metabolism varies between individuals depending on the population of gut microbiota, much attention paid to the transformation of major ginsenosides into more pharmacologically active ginsenosides using diverse methods including heating, acid hydrolysis, microbial conversion, and enzymatic treatment. Recently, in food and drug industry and academia, the development of fermented ginseng products using probiotic bacteria is being intensively studied due to the potential health benefits of ginsenoside metabolites and probiotics. This review summarizes recent studies on the metabolism of ginsenoside by gut microbiota and biotransformation of ginsenoside using lactic acid bacteria and their enzymes.

서론

Ginsenoside의 구조적 특성

인삼 가공처리에 의한 ginsenoside 전환

Ginsenoside의 대사에서 장내미생물의 역할

유산균 발효 및 효소를 활용한 ginsenoside의 생물전환

결론