로타바이러스 감염된 Vero 세포에서 Lactobacillus ruminus와 Bifidobacterium longum의 케모카인 변화 분석

Chemokine Effects of Lactobacillus ruminus, and Bifidobacterium longum in Rotavirus Infected Vero Cells

Probiotics, such as Lactobacillus spp. and Bifidobacterium spp. are reported to have the multiple potential health benefits including blocking gastroenteric pathogens, reduce gut permeability, enhancing immune response and anti-viral effects. In this study, we explored whether LR211 and BL205, 206 exert on MCP-1 and IL-8 chemokines responses in rotavirus infected vero cells. And we investigated anti-rotaviral activity of Lactobacillus spp. and Bifidobacterium spp. isolated against rotavirus by plaque assay. As a results, all of them were not toxic to vero cells. Three probiotics, BL205, 206 and LR211, increased release of MCP-1 and IL-8 in Wa rotavirus infected vero cells compared to control. This anti-viral effects of LR211 and BL205, 206 can be explained that they modulate immune response by inducing MCP-1 and IL-8 chemokines.