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Proposed Pathway Linking Respiratory Infections with Depression
- 대한정신약물학회
- Clinical Psychopharmacology and Neuroscience
- Clinical Psychopharmacology and Neuroscience Vol.20 No.2
- : SCOPUS, SCIE, KCI등재
- 2022.05
- 199 - 210 (12 pages)
Depression is one of the most important causes of disability and loss of useful life of people around the world. Acute respiratory infection caused a large number of severe illnesses and deaths of the world and most of these due to viral infections, which is estimated more than 80% of respiratory infections. Detection of viruses by immune pathogen recognition receptors activates the intracellular signaling cascade and eventually cause produces interferons. Inflammatory process begins with secretion of interferons and the expression of interferon-stimulated genes. One of the most important of these genes is indoleamine-pyrrole 2,3-dioxygenase (IDO), which plays a major role in tryptophan catabolism. IDO is an intracellular monomeric enzyme that is also responsible for breaking down and consuming tryptophan in the Kynurenine pathway. Increased inflammation has been linked to decrease tryptophan concentrations and increase kynurenine levels. We tried to explain the role of inflammation by viral respiratory infections in causing depression.
INTRODUCTION
VIRAL RESPIRATORY INFECTION
INFLAMMATION IN VIRAL RESPIRATORY INFECTION
ROLE OF IDO IN TRYPTOPHAN CATABOLISM AND KYNURENINE PATHWAY
TRYPTOPHAN AND SEROTONIN METABOLISM
ROLE OF SEROTONIN IN DEPRESSION
EPIGENETICS FINDING
THE LINK BETWEEN INFLAMMATORY RESPONSE IN VIRAL RESPIRATORY INFECTION AND DEPRESSION
CONCLUSION