Chondromyxoid fibroma (CMF) is a rare benign cartilaginous tumor that usually arises from metaphysis of the long bone of the lower extremities. Only 1%-5% of CMF occurs in the head and neck and few cases of sinonasal CMF have been reported. Because sinonasal CMF and chondrosarcoma have common radiologic and pathologic feature, it is difficult to distinguish from chondrosarcoma. However fast and accurate diagnosis is important because mortality of chondrosarcoma is nearly 50%. This report describes one case of skullbase CMF attached to posterior septum and rostrum of sphenoid bone, mimicking chondrosarcoma in radiologic findings. We tried to share diagnostic and therapeutic process of skullbase CMF which occurred in unusual location, and elaborate differentiating points of cartilage neoplasms in the nasal cavity which have completely different prognosis.
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