目的：分析带量采购对中选与非中选抗高血压类药品的使用影响，为政策制定及医院合理用药提供参考。方法：以抗高血压药为例，采用实证研究对某院带量采购实施前后一年的数量、金额、用药频度（DDDs）、日均费用（DDC）、仿制药替代率及费用节省等情况进行比较分析。结果：实施带量采购后，抗高血压类药品总体使用量上升 18.60%，销售额下降 7.71%，仿制药对原研药的替代率为 65.07%，潜在节省费用 489.44万元，较带量前实际节省费用 545.78 万元。结论：带量采购实施后，仿制药中选品种呈价减量增的趋势，对原研药的替代率有显著提升，极大缓解了高血压类疾病患者用药负担。
Objective: To analyze the influence of the volume-based procurement policy on the use of antihypertensive and to provide reference for policy formulation and rational drug use in hospital. Methods: Take antihypertensive for examples, empirical approach was used to analyze sales amount, sales volume, generics substitution rate etc., comparing the policy before and after implementation. Results: After the implementation of the volume-based procurement policy, the overall use of antihypertensive drugs increased by 18.60%, and sales fell by 7.71%. Under the effect of the same curative efficacy, the substitution rate of generic drugs for the original drugs was 65.07%, and the potential cost saving was 4.89 million yuan, which is 5 457 800 yuan in actual cost savings compared with before the implementation of the volume-based procurement policy. Conclusion: After the implementation of volume-based procurement policy, the selected varieties of generic drugs showed a trend of decreasing prices and increasing volume, significantly increasing the replacement rate of original research drugs, which effectively alleviated the burden of medication for patients with hypertensive diseases.