Purpose: Today, the population with hair loss is decreasing in age given various factors, and due to such, the market for scalp and hair cosmetics is exploding. Due to the growing interest in side effects such as allergies and environmental pollution, recently, many studies have been conducted to find cosmetic raw materials from natu-ral substances or to apply fermentation techniques to the cosmetic manufacturing process. Hence, after enzy-matic fermentation with Smilax china, which has been used for various pharmacological functions in the private sector for a long time and has secured clinical safety, the active ingredients and effectiveness(in vitro) were ex-amined. Method: After preparing a sample by the enzymatic fermentation of Smilax china, which is known to have various pharmacological actions, with malt, the active ingredients and effectiveness(in vitro, HaCaT cell protec-tive effect against oxidative stress, antibacterial activity, anti-inflammatory activity, dermal papilla cell prolifer-ation rate) was confirmed. Results: As a result of the experiment conducted, the fermented Smilax china enzyme had excellent antibac-terial activity, HaCat cell protective effect against oxidative stress, anti-inflammatory activity, and dermal papilla cell proliferation rate, respectively. Conclusion: It was confirmed that the fermented product obtained by fermenting Smilax china malt with malt offers the excellent HaCat cell protection effect against the oxidative stress, antibacterial activity, anti-inflam-matory activity, and the dermal papilla cell proliferation rate, and hence, it can be applied as a raw material for various cosmetics. In particular, the usefulness as a cosmetic material for scalp and hair that is effective for the health of the scalp and hair was confirmed. Future research is expected to articulate the pharmacological mech-anisms of the Smilax china fermented products through the physiological studies related to the fermentation process and the growth rate of dermal papilla cells.
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