Claw fracture disease can often be encountered in veterinary medicine, but the rate of visits related to claw diseases in South Korea has not been accurately investigated. This case is about systemic inflammation after a toenail fracture. A 2-year-old male, a Pomeranian dog visited the animal medical center with acute vomiting and anorexia after undergoing declawing for a fractured claw at another hospital. To evaluate the cause of vomiting, blood tests, X-rays, and abdominal ultrasonography were performed. In blood tests, C-reactive protein and D-dimer levels were 105 mg/L and 560.05 ng/ml, respectively, which were higher than normal, and the cPL kit test was negative. At the time of admission, the affected area was not properly protected and did not coalesce with a purulent exudate. It was judged that the cause of vomiting was an inflammatory reaction that progressed throughout the body. Therefore, an antibiotic injection and fluid treatment were performed during hospitalization, and the affected area was treated with sugar dressing 4 times a day. As the inflammation level gradually improved, the clinical symptoms also improved. Therefore, this case suggests the importance of correct postoperative management after initial claw damage and declawing from the animal health point of view.