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This study performed a fatigue test under the simulated body environment that has reflected factors (such as body fluids, saliva) within a living body. First, this study tried to evaluate the fatigue limit under normal condition and simulated body environment and to look into the governing factors of implant fatigue strength through the observation of fracture mode. The fatigue limit of implant within the simulated body environment has decreased by 19% as compared to that of normal condition. Also the fatigue life of implant under the saliva environment has decreased as compared to that of ringer environment condition. The implant fracture under the ringer environment is mostly governed by the fatigue failure of abutment screw and accordingly, the influence made by the fixture on the fatigue strength of implant could be said as small. But the implant fracture mode under the saliva environment is governed by the fatigue failure of fixture. The corrosion products were observed on the implant from the fatigue test of simulated body environment. The corrosion products which were generated on the saliva specimen is much more than that of ringer specimen. It is judged that the stronger corrosion behavior in the saliva specimen as compared to that of ringer specimen have led to the overall decrease of fatigue life.