Purpose : This study aimed to identify the effects of daytime sleepiness, depression, and quality of life on the academic achievement of nursing students. Methods : The subjects of the study were 250 students attending two nursing universities located in the City of C or Y. The study was conducted from October 17, 2022 through October 31, 2022 by using the self-reported questionnaire. The collected data were analyzed by using descriptive statistics, independent t-test, one-way ANOVA, Pearson’s correlation coefficient, and the hierarchical multiple regression using the SPSS win. 26.0 program. Results : The academic achievement of the nursing students was negatively correlated with daytime sleepiness (r＝-.27, p＜.001), depression (r＝-.38, p＜.001). however it was positively correlated with quality of life (r＝.49, p＜.001). The most influential factor for the academic achievement was the quality of life (β＝.37, p＜.001), followed by daytime sleepiness (β＝-.13, p＝.031), and depression (β＝-.13, p＝.044), which together explained their academic achievement up to 32.4%. Conclusion : In order for the nursing college students to successfully perform their duties as professional nurses after graduation, effective strategies are needed to reduce daytime sleepiness and depression and improve the quality of life during college.