Objectives This study aimed to report the effects of giant cell tumor treatment to a patient who had cervical and lumbar pain and hypoesthesia of the limbs after total spondylectomy with Korean medicine. Methods A 67-year-old female patient with cervical and lumbar pain and hypoesthesia of the limbs after total spondylectomy was treated with herbal medicine (Cheongpa-jeon, Yukkongbaro-hwa), acupuncture, pharmacopuncture, and physical therapy for 36 days. The effects were evaluated using a numerical rating scale (NRS), Neck Disability Index (NDI), Oswestry Disability Index (ODI), and EuroQoL-5D (EQ-5D). Results After treatment, changes were observed in the patient’s pain and hypoesthesia. NRS, NDI, ODI, and EQ-5D scores decreased. Conclusions This case study suggests that Korean medicine treatment may be effective for symptomatic treatment in patients with giant cell tumor following total spondylectomy.