트레드밀 운동이 알코올 섭취로 유도된 쥐의 간 손상에 미치는 영향

Effect of Treadmill Exercise on Liver Damage Induced by Alcohol Consumption in Rat

Purpose: The purpose of this study is to investigate the liver function improvement effect of treadmill exercise on liver damage in rats induced by alcohol consumption. Method: Fifteen male Sprague Dawley (SD) rats were randomly assigned to CO (control group, n=5), AC (alcohol consumption, n=5) ACE (alcohol consumption + exercise, n=5). The treadmill exercise consisted of five times a week for five days and lasted 60 minutes (5 min for warm-up, 50 min for the main exercise, and 5 min for cool-down). Blood samples were taken after 5 weeks of exercise, and serum alanine transaminase (ALT) and aspartate transaminase (AST) were measured using an ELISA kit. The data were analyzed using one-way ANOVA to verify between-group differences in weight and liver damage index. If there was a statistically significant difference, Tukey's post-hoc was performed. Results: There was no weight change after five weeks of exercise intervention. However, ALT and AST were statistically significantly higher in the AC group than in the CO group and the ACE group(p<0.001). Conclusion: In conclusion, treadmill exercise for 5 weeks improves liver function and reduces ALT and AST against alcohol-induced liver damage.