상세검색
최근 검색어 전체 삭제
다국어입력
즐겨찾기0
약학회지 제67권 제1호(2023년).jpg
KCI등재 학술저널

Immunomodulatory Role of Neuropeptide Y in Intestinal Inflammation

Immunomodulatory Role of Neuropeptide Y in Intestinal Inflammation

DOI : 10.17480/psk.2023.67.1.1
  • 35

Neuropeptide Y (NPY) is a 36-amino acid peptide found in the brain, autonomic nervous system, and different peripheral tissues, including the gastrointestinal (GI) tract. Dysfunction of the NPY or NPY system has been implicated in various tumor microenvironments and cardiovascular and GI disorders, such as inflammatory bowel disease (IBD). IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a major health concern due to its increasing incidence globally. Emerging evidence has demonstrated that NPY also acts as a potent immunomodulator by linking the nervous and immune systems. NPY plays an important role in immunopathology during intestinal inflammation. This paper discusses the potential role of NPY as a valuable biomarker for IBD due to its consistent upregulation in both in vivo and clinical studies. Consequently, it confirms the pro-inflammatory effects of NPY, providing a rational basis for targeting NPY signaling as a therapeutic strategy.

Introduction

Localization of NPY in the gut

Inflammatory bowel disease

Alteration of NPY expression during colitis

Role of NPY in intestinal inflammation

NPY as an immune modulator in IBD

Conclusion

Acknowledgment

Conflict of Interest

References

로딩중