
Endothelial cell autophagy in the context of disease development
- Basheer Abdullah Marzoog
- 대한해부학회
- Anatomy and Cell Biology
- Vol.56(1)
- 등재여부 : KCI등재
- 2023.03
- 16 - 24 (9 pages)
Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.
Introduction
Potential Endothelial Cell Autophagy Triggers and Mechanism
Types of Endothelial Cells
Autophagy in Endothelial Cell Aging as a Marker
Current Approaches for Future Therapeutic Strategy
Discussion
Conclusion
ORCID
Author Contributions
Conflicts of Interest
References