Neck pain is an extremely common symptom with a variety of potential etiologies. A significant number of patients are turning to complementary and alternative medicine therapies. In particular, chiropractic and osteopathic manipulation techniques are discussed. “Low quality evidence”, as per the GRADE system criteria used by the Cochrane Review, supports the beneficial effects of these treatments Complications are generally benign and self-limited although occasional catastrophic consequences have been documented. Medical practitioners should familiarize themselves and their patients with the risks and benefits of complementary and alternative medicine in order to make informed decisions.