Ephedra and ephedra alkaloids are sympathomimetic compounds extracted from the genus Ephedra. They have been used to treat colds and provide cough relief for centuries in oriental medicine. Recently, it has been reported that Ephedra plays a crucial role in weight loss and the enhancement of athletic performances. However, the overuse of Ephedra causes cardiovascular side effects such as increases in blood pressure, heart rate, and palpitations. Ephedra’s adverse effects also were mentioned in Shan Han Lun, a famous formulary in traditional Chinese medicine. The present study demonstrated Ephedra’s effects and the deficiency of Yang due to the overuse of Ephedra.