네트워크약리학을 이용한 소건중탕 활성성분 및 잠재적인 타겟 효능 예측

A Network Pharmacology-Based Analysis of Sogunjung-tang to Investigate Active Compounds and Their Potential Targets

Objectives: Due to the complex interactions among the multiple compounds of herbs or herbal formulations, there has been demand for systemic assessment for understanding the therapeutic effect of herbal formulations. To address this, here we introduced the network pharmacology based analysis to explore the potential targets and mechanisms of Sogunjung-tang. Methods: Active compounds of Sogunjung-tang were searched, and their target genes were collected from databases (TCMSP, STRING). Then network analysis was performed to visualize the interaction of herbs - compounds - target genes (Cytoscape). Gene Ontology and KEGG pathway analysis of target genes were also conducted to find out the associations with biological processes and pathways. Results: We identified 34 major active compounds and their 282 associated target genes of Sogunjung-tang. Gene Ontology analysis displayed the target gene enriched biological processes, which were oxidation-reduction and inflammatory response related groups. KEGG pathway analysis results also demonstrated the representative pathways including, antioxidant pathways, anti-inflammatory pathways, cancer pathways and neural pathways. Conclusions: Thus, these data provide a systematic way to understand and estimate the multiple targets and therapeutic actions of Sogunjung-tang.