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The Study of Herbal Medicines Acting on Brain-derived-neurotrophic-factor (BDNF)

Background: Although neurological disease is the high Global burden diseases in the worldwide, it is difficult to develop new drugs. Many reviews have been assessed on whether herbal medicine has the potential to be developed as a treatment for neurological diseases and BDNF target. Method: A total of 242 articles were searched using “Herbs and BDNF” as the keyword among the articles searched in PUBMED since 2003. The final 164 articles were selected and analyzed. Result: A total of 61 herbs, 9 fractions, 40 compounds, and 56 formulae were evaluated to act on BDNF, and BDNF expression was increased in almost herbal medicines and suggest the possibilities of nerve regeneration effects. Conclusion: The results that herbal medicines increase the expression of BDNF suggest that it can be developed as a therapeutic agent for BDNF-related neurological diseases-Dementia, Parkinson's, neuralgia, epilepsy etc.