연구목적 본 연구는 간편하면서도 유용하게 사용될 수 있는 치매 선별용 인지기능 검사 도구인 Memory Impairment Screen(MIS)를 한국어판(MIS-K)으로 구성하여 그 신뢰도와 타당도를 검증하고자 한다. 방 법 최종적으로 정신과 전문의의 진단을 거친 총 124명(치매 34명, 정상 90명)의 참여자들을 대상으로 MIS-K의 신뢰도와 공존타당도를 검증하였고, MIS-K의 총점에 따른 최적 절단점의 민감도 및 특이도를 산출하였다. 결 과 MIS-K는 높은 내적 일치도와 함께 우수한 평가자간 및 검사-재검사 신뢰도를 보였다. MIS-K는 B-ADL(Korean version of Bathel ADL Index), L-IADL(Korean version of Bathel ADL Index), MMSE-KC, BDS-K(Korean Behavioral dyscontrol scale) 및 GDS(geriatric depression scale)와 유의한 상관관계를 보였으며, ROC 곡선분석을 통해 추정된 최적 절단점(5/6) 에서의 민감도와 특이도가 각각 0.94, 0.93으로 높게 나타났다. ROC곡선의 Area Under Curve(AUC) 분석결과 MIS-K는 MMSE-KC와 치매선별도구로서 상대적으로 우수한 진단적 효율성을 보였다. 결 론 한국어판 MIS(MIS-K)는 높은 신뢰도와 타당도를 가지고 있으며, 치매선별을 위해 간편하면서도 유용한 인지기능 평가 도구이다.
The aims of this study are to develop the Korean Version of Memory Impairment Screen(MIS-K) by analyzing reliability and validity, and to show its usefulness as a dementia screening instrument. A total of 124 participants(34 dementia vs. 90 normal control) were confirmed the final diagnosis by psychiatrist. All of them were administered MIS-K, B-ADL(Korean version of Bathel ADL Index), L-IADL(Korean version of Bathel ADL Index), MMSE-KC, BDS-K(Korean Behavioral dyscontrol scale) and GDS(geriatric depression scale). Inter-rater reliability, test-retest reliability and internal consistency of MIS-K were analyzed. To verify the concurrent validity of MIS-K, correlations with other tests(MMSE-KC, B-ADL, L-IADL, MMSE-KC) were analyzed. The sensitivity and specificity for each cut-off point of MIS-K were estimated and the Receiver Operator Characteristic (ROC) curve method was performed to get its optimal cut-off point. MIS-K was found to have significantly high internal consistency, inter-rater reliability, and test-retest reliability. The significant correlations of MIS-K with other tests were also shown. Its optimal cut-off point was estimated as 5/6, and the sensitivity and specificity were 0.94 and 0.93, respectively. The ROC curve analysis indicated that the diagnostic efficiency of MIS-K was comparable with MMSE-KC. We conclude that MIS-K has not only high reliability and validity, but also usefulness as a screening instrument for dementia.
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