일 지역사회 코호트에서 정상 노인군과 경도인지장애군의 알츠하이머 치매로 진행하는 위험율 비교

The Conversion Rates Difference to the Alzheimer Dementia between the Normal Elderly Group and the Mild Cognitive Impairment Group in One Community Cohort：18 Months ’ Prospective Follow-up Study

국내 지역사회 거주 노인을 대상으로 한 이번 연구에서 경도인지장애가 있는 경우는 그렇지 않은 경우에 비해 18개월 후 알츠하이머 치매로 진행할 확률이 통계적으로 유의하게 높았다. 따라서 지역사회에서 경도인지장애가 있는 노인을 선별하고, 그들을 대상으로 알츠하이머 치매로의 진행을 늦출 수 있는 적절한 개입을 하는 것이 중요하다.

Objectives：The aim of this study is to compare the conversion rates to Alzheimer dementia between the normal elderly group and the mild cognitive impairment group at the community cohort. Methods：Among the 229 nondemented elderly who had undergone the first wave in 2006, 70 subjects completed the second wave 18 months later. We used the Korean version of Mini Mental Status Exam(MMSE-K), the Korean version of the CERAD(Consortium to Establish a Registry for Alzheimer’s Disease) neuropsychological batteries, the Korean version of Geriatric Depression Scale, and the Instrumental Activities of Daily Living scale. Psychiatrists diagnosed mild cognitive impairment and Alzheimer dementia by Petersen criteria and Diagnostic and Statistical Manual of Mental Disorders fourth edition(DSM-IV) criteria. We used the multivariate logistic regression to calculate the odds ratio for the conversion to Alzheimer dementia between two groups. Results：While only one subject converted to Alzheimer dementia among 43 normal elderly(2.3%), there were 5 Alzheimer dementia conversions out of 21 mild cognitive impairment cases(23.8%). The odds ratio between two groups is about 30. No other clinical variables predicted progression toward Alzheimer dementia. Conclusion：The elderly with mild cognitive impairment has higher risk of conversion to Alzheimer dementia than the normal elderly in the community cohort.