국내 만성신장질환자에서 나타나는 요산과 빈혈과의 관련성

The relationship between uric acid and anemia in Korean adults with chronic kidney disease

본 연구는 만성신장질환이 있는 한국 성인의 고요산혈증과 빈혈과의 관계를 알아보기 위해 제8기 국민건강영양조사(2019~2021)를 바탕으로 20세 이상의 성인 557명의 자료를 분석했다. 본 연구에서는 몇 가지 주요한 결과가 있었다. 관련 변수를 조정한 후, 정상요산군(남성, 요산[uric acid, UA] < 7.0 mg/dL; 여성, UA < 6.0 mg/dL)에 비하여 고요산혈증군(남성, UA ≥ 7.0 mg/dL; 여성, UA ≥ 6.0 mg/dL)의 빈혈 발생 교차비(odds ratio, OR)는 남성(OR, 2.008; 95% confidence interval [CI], 1.013–3.165)과 여성(OR, 2.246; 95% CI, 1.315 –3.835) 및 만성신장질환 전체(OR, 1.719; 95% CI, 1.371–2.942)에서 유의하게 높았다. 결론적으로 고요산혈증은 만성신장질환을 가진 한국인 남녀 모두에서 빈혈 증가와 관련이 있었다.

The present study was conducted to assess the relationship between hyperuricemia and anemia in Korean adults with chronic kidney disease (CKD). Data from 557 adults (age ≥ 20 years) in the Eighth Korean National Health and Nutrition Examination Survey (2019–2021) were analyzed. Several key findings were identified. First, after adjusting for the related variables, the odds ratio (OR) of anemia (hemoglobin [Hb] < 13.0 mg/dL in men or < 12 mg/dL in women), using the normouricemia group (uric acid [UA] < 7.0 mg/dL in men or < 6.0 mg/dL in women) as a reference, was positively significant for the hyperuricemia group (uric acid [UA] ≥ 7.0 mg/dL in men or ≥ 6.0 mg/dL in women) in overall population (odds ratio [OR], 1.719; 95% confidence interval [CI], 1.371–2.942), men (OR, 2.008; 95% CI, 1.013–3.165), and women (OR, 2.246; 95% CI, 1.315–3.835). In conclusions, hyperuricemia was associated with an increase in anemia in both Korean men and women with chronic kidney disease.