Age-related macular degeneration (AMD) is the most frequent cause of vision loss in the elderly, and there is currently no effective treatment. Recently, many studies have attempted to reduce the risk of conversion to late AMD through lifestyle correction, smoking cessation and exercise. Several studies have also found that taking supplements orally can help prevent disease progression. Nutritional supplements consisting of vitamin C, vitamin E, beta-carotene, zinc, and copper were taken in the Age-Related Eye Disease Study (AREDS) 1, and lutein and zeaxanthin were recommended instead of beta-carotene in AREDS 2. This review focuses on the role of supplements in the prevention of AMD and summarizes the current issues about the most frequently used micronutrients.
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