갑상샘 스캔 정량분석을 통한 갑상샘 섭취율 동시계측법 연구

Study of Simultaneous Counting of Thyroid Uptake with Quantitative Analysis of Thyroid Scans

Thyroid uptake measurements can be subject to measurement errors due to the scoping and positioning of the thyroid gland. To compensate for these limitations, the clinical utility of the thyroid simultaneous counting method as an alternative to thyroid uptake measurement was analyzed and evaluated experimentally through quantitative analysis of im-ages acquired after thyroid scanning. Experimental data were obtained using a Gamma camera (GE infinia), a thyroid up-take system (KOROID 1), and a thyroid neck phantom. Based on the thyroid uptake rate of 1-5% according to the proto-col of thyroid scan test (99mTcO4-, 370 MBq) in normal results, 99mTcO4- was set in the range of 3.7-18.5 MBq (Matrix: 256×256, Scan time: 1 min, collimator: pin hole, phantom-collimator distances: 7 ㎝). The acquired images were corrected for the attenuation of isotopes due to the set-up time and half-life by applying the Auto Region of interest (ROI) drawing system, and the significance of the experimental results was evaluated by Multiple linear regression analysis (SPSS, ver. 22, IBM). The thyroid uptake rate showed a significant correlation between the dose and the measured counts when us-ing the thyroid uptake system equipment. Meanwhile, the quantitative analysis counts of phantom images using Gamma camera also showed a significant correlation. Thus confirmed that the correlation between these two experiments was stat-istically significant (P<0.05). The simultaneous counting protocol, which indirectly measures thyroid uptake from thyroid scans, is likely to be clinically relevant if complemented by additional studies with different variables in patients with thy-roid disease.