동물모델을 이용한 병풀의 항아토피 효능 평가

Evaluation of Anti-atopic Efficacy of Centella asiatica using Animal Model

Centella asiatica (C. asiatica) is currently widely used in wound healing and has recently been reported to have immune suppressive properties. Atopic dermatitis (AD) is a chronic inflammatory and allergic disease. We herein investigated the anti-atopic effect of C. asiatica in vivo. To examine the anti-atopic dermatitis activity of C. asiatica the ovalbumin-induced BALB/c mouse model was used. Ovalbumin mixture was injected into the abdominal cavity and patched on the back to induce AD, and then treated by orally administering C. asiatica. C. asiatica reduced major signs of clinical skin severity such as erythema, pruritus, lichenification, edema/escoriations, and dryness. A decrease in the number of scratch was also seen in scratching counts. The level of serum IgE was also reduced in mice treated with C. asiatica. We therefore suggested C. asiatica extract can be used as a therapeutic agent for AD treatment.