문헌 분석을 통한 소아청소년 감초 처방의 안전성 고찰

A Study on the Safety of Glycyrrhiza Uralensis for Pediatrics through Literature Analysis: focusing on Glycyrrhizin

Objectives: This study was conducted to review safety of herbal medicine for pediatrics, especially Glycyrrhiza uralensis, and to design herbal medicine safety assessment model. Methods: Literature search was done to study safety of herbal medicine for pediatrics, especially Glycyrrhiza uralensis. UptoDate, Pubmed, Google Scholarship, DBPIA were used in the research. Search words were ‘pediatrics AND herbal medicine’, ‘Safety of Herbal medicine’, ‘Glycyrrhiza uralensis’, etc. Results: 5 steps of herbal medicine safety assessment model were planned and done. Those include chemical structure analysis, pathologic analysis, pharmokinetics analysis, dosage - toxicology analysis, bibliographic analysis. Through the 5 assessment steps, we estimated that pseudo - aldosteronism’s risk factor can be infants below 12 months, constipation, low albumin levels. We also estimated the safety standard for the herbal medicine and the calculation were same by dosage - toxicology and bibliographic analysis. We also found out that while reading medical book from past, the doctor should pay attention to drug taking methods. Conclusions: 5 steps of herbal medicine safety assessment model should be introduced to other herbal medicines for fast assessment by the doctors before prescripting to pediatrics. However, backup experimental data, safety clinical trials for pediatrics should be more held for further evidence.