상세검색
최근 검색어 전체 삭제
다국어입력
즐겨찾기0
한국구강보건과학회지 제11권 제4호.jpg
학술저널

흰 쥐의 만성 통증모델에서 구강건조증이 c-fos 발현에 미치는 영향

Effects of Xerostomia on C-Fos Expression in a Chronic Pain Model in Rats

DOI : 10.33615/jkohs.2023.11.4.91
  • 99

Objectives: The purpose of this study was to determine whether xerostomia could improve the level of neuropathic pain. To conduct the study, the change in c-fos expression level in the medulla oblongata was confirmed by xerostomia induction using the chronic neuropathic facial pain model. Methods: mal-positioned dental implant surgery was performed on the extraction site of the mandibular second molar of rats, and 4-diphenylacetoxy-N- methylpiperidine (4-DAMP) (30mg/kg) was injected intraperitoneally after a pain test on the 4th day after surgery. c-fos was counted only in the lamina I and II regions. Results: A significant increase in c-fos expression was observed when the maxilla was stimulated compared to the mandible in the group induced both neuropathy and xerostomia. Conclusions: Therefore, it is considered that xerostomia in the facial area is the cause of the expression of chronic pain and the improvement of pain sensation.

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 연구결과

Ⅳ. 고찰

Ⅴ. 결론

참고문헌

로딩중