월경주기에 따른 18F-FDG PET/CT의 자궁 내 섭취에 관한 연구

Ovarian and Endometrial 18F-FDG Uptake During the Menstrual Cycle in Normal Premenopausal Patients: Evaluation by PET/CT

Purpose: The menstrual cycle of normal premenopausal patients was divide into menstrual flow phase, proliferative phase, ovulatory phase, secretory phase. The aim of this study was to ovarian and endometrial 18F-FDG uptake during the menstrual cycle in normal premenopausal patients. Materials and Methods: We identified 200 incidental 18F-FDG uptake in the ovary. The patient fasted at least 6 hours before receiving an intravenous injection of 370-592 MBq (10-16mCi) of 18F-FDG. Scanning from the base of the skull though the mid thigh was performed using the Discovery Ste PET/CT system (GE Healthcare, Milwaukee, WI, USA). Ovarian and endometrial 18F-FDG uptake (expressed as standardized uptake value) was measured on PET/CT image. Results: Two peaks of increased endometrial 18F-FDG uptake were identified during the menstrual cycle. The SUVavg and SUVmax was 2.89±1.04 and 3.17±1.59 in menstruating patients, 2.4±0.88 and 2.98±1.14 in proliferative phase patients, 3.59±1.76 and 3.17±1.67 in ovulatory phase patients, 2.58±1.39 and 3.1±1.8 in secretory phase patients. Conclusions: Increased ovarian and endometrial 18F-FDG uptake could be found the time of menstrual flow and ovulatory phase of menstrual cycle. Increased uptake in endometrial adjacent to a cervical tumor does not necessarily reflect endometrial tumor invasion. Since increased uptake was dependent on the menstrual cycle, it can be avoided by scheduling PET/CT just after menstruation. Non-menstrual-related endometrial uptake may be instrumental in establishing a diagnosis in a premenopaual patient.