부갑상선 신티그라피를 시행한 환자들의 병소 국소화에 따른 후향적 분석연구

Quantitative Analysis of ⁹⁹ᵐTc-MIBI Scan for Localization of Parathyroid Lesions

Purpose: The uptake of ⁹⁹ᵐTc-MIBI increases in the parathyroid adenoma, hyperplasia, and carcinoma. The purpose of this study is to evaluate and compare the results of the biopsy with quantitative analysis results in the localized parathyroid lesions (adenoma, hyperplasia, and carcinoma). Materials and Methods: From April 2002 to January 2009, double-phase ⁹⁹ᵐTc-MIBI parathyroid scan (early 15 min, delayed 2 hrs) was performed after injection of 750 MBq of ⁹⁹ᵐTc-MIBI in 27 diagnosed parathyroid patients (adenoma:15, hyperplasia:4, carcinoma:8). For quantitative analysis, early, delayed lesion to non-lesion ratios (L/NLs), washout rate (%, WR) and vertical axis were calculated. Results: In early images, lesion to non-lesion ratios were 1.53±0.41 (adenoma), 1.38±0.27 (hyperplasia) and 1.45±0.64 (carcinoma). In delayed images, lesion to non-lesion ratios were 1.56±0.43 (adenoma), 1.33±0.10 (hyperplasia), 1.83±0.79 (carcinoma). In vertical axis , the sizes were 2.11±0.67 (adenoma), 2.23±0.75 (hyperplasia) and 2.20±0.97 (carcinoma). There was no statistical difference between lesion to non-lesion ratios and the size of vertical axis (p>0.05). However, washout rates were 31.59±13.97 (adenoma), 37.8±5.69 (hyperplasia), 17.73±11.02 (carcinoma). As a result, there was a significant difference statistically between and that of carcinoma (p<0.05, p=0.028 by Kruskal-willis statistic, Dunn’s Multiple comparison test SPSS Ver 12.0). Conclusions: There was no statistical difference between the lesion to non-lesion ratios and the size of vertical axis. However, there was a significant difference statistically between WR of hyperplasia and that of carcinoma.