FDG 합성 후 질소가스를 이용한 튜빙의 잔류 ¹⁸F-FDG 최소화를 위한 방법의 유용성

A Study on Minimizing the Residual ¹⁸F-FDG in the Tubing Using Nitrogen Gas

Purpose: In ¹⁸F-FDG automated synthesizer, deliver is done in automated mode after synthesis until the dispenser. After the delivery, the yield is calculated from the radioactivity which was read by the dose calibrator located in the dispenser. However, when the distance between the automated synthesizer and the dispenser is far, there are ¹⁸F-FDG residues, which results in loss of the amount of ¹⁸F-FDG. This study investigated the usefulness of a method that minimizes ¹⁸F-FDG residues. Materials and Methods: The structure of the tubing between the (TRACERlab Mx FDG; GE.) and the dispenser is that the distance is 8 m and the internal diameter is 1/16 inch. The synthesis process of The module goes through the synthesis process of trap, synthesis, delivery in the automated module. The time taken for synthesis is about 25 to 26 minutes, after which rinsing is done. However, after rinsing, as the distance of the tubing increased, there were 10~13% of ¹⁸F-FDG residues. Therefore, a method of using push syringe and N2 gas in manual mode to minimize ¹⁸F-FDG residues is analyzed. Results: In manual mode, there were ¹⁸F-FDG residues of 4~5% for the push syringe, and there were ¹⁸F-FDG residues of less than 1% for the N2 gas, which showed that the method using N2 gas had superior usefulness. Also, there were no ¹⁸F-FDG residues in the cleaning the next day. Conclusion: The distance between the synthesizer and the dispenser needs to be reduced as much as possible, to reduce the rate of loss of ¹⁸F-FDG resulting from the distance of the tubing. However, in case the distance between the synthesizer and the dispenser has to be increased due to the system structure, using push syringe and N2 gas simultaneously is a useful method for minimizing ¹⁸F-FDG residues.