⁹⁹ᵐTc 발생기의 24시간 내 2회 용출의 유용성 평가

The Evaluation of Usefulness of Two Times Elution a Day of ⁹⁹ᵐTc Using ⁹⁹ᵐo-⁹⁹ᵐTc Generator

Purpose: The Molybdenum which is the raw material of ⁹⁹ᵐo-⁹⁹ᵐTc generator (generator) is produced from the nuclear reactor. However, output has dwindled as the two nuclear reactors supplying the bulk of radioactive material-one in Chalk River, Ontario and the other in Petten, the Netherlands-have been closed for repairs or maintenance. This resulted in the enhancement of its price. Therefore we have tried to seek the new method which could run generator to increase activity of ⁹⁹ᵐTc in this study. Materials and Methods: The ⁹⁹ᵐTc activity obtained from 5 times elution for 5 days from Monday to Friday using two generators was compared with 10 times elution. Appearance test, pH test, LAL test, sterility test, chemical impurity(Al) test, radio chemical purity test, ratio of ⁹⁹ᵐo/⁹⁹ᵐTc activity test have been done to check the stability of ⁹⁹ᵐTc eluting from generator respectively. Results: The ⁹⁹ᵐTc activity obtained from 5 times elution for 5 days was 168.2 GBq (4545 mCi) and 10 times was 230.5 GBq (6230 mCi). All quality control tests were within normal limit. Conclusion: We got to know that 2 times elution a day obtained more ⁹⁹ᵐTc activity than one time elution in this study.