조영증강 18F-FDG PET/CT가 이중에너지 X-선 흡수 계측법을 이용한 골밀도 및 체성분 측정에 미치는 영향

Effect of Contrast-Enhanced 18F-FDG PET/CT on Measurements of Whole Body Bone Mineral Density and Body Composition by Dual-Energy X-Ray Absorptiometry

Purpose : The effect of concomitant use of 18F-FDG and intravenous contrast agent (CA) on dual-energy X-ray absorptiometry (DXA), was rarely reported. We had investigated these potentially confounding effects. Materials and Methods : Twenty-two patients had undergone DXA before and immediately after 18F-FDG PET/CT scans. Two DXA and 1 PET/CT scans had performed within one-day. 18F-FDG PET/CT scans had been performed with CA in 17 patients and without CA in 5 patients. Whole body bone mineral content (BMC), whole body bone mineral density (BMD), total fat mass (TFM), and lean body mass (LBM) were measured by DXA scanner before and after the 18F-FDG PET/CT scans. Results : BMC, BMD, TFM and LBM had significantly affected by 18F-FDG PET/CT with CA (BMC, +13.7%, from 2061.3±393.7 to 2343.4±373.3; BMD, +9.3%, from 1.07±0.09 to 1.17±0.08; TFM, -34.1%, from 17052.1±4049.9 to 11237.1±2990.3; LBM, +13.6%, from 45834.5±5662.1 to 52094.0±6335.4). However, 18F-FDG PET/CT without CA had no effect on the measurement of DXA (BMC, +2.4%, from 2197.7±391.6 to 2251.5±380.9; BMD, +1.8%, from 1.13±0.09 to 1.15±0.07; TFM, -6.8%, from 14585.6±3455.9 to 13591.3±4351.4; LBM, +2.2%, from 47360.5±8381.8 to 48441.1±8488.1). Conclusion : The measurements of DXA are affected by using CA. However, DXA scans might be unaffected by the presence of 18F-FDG administered for PET/CT.