전신 뼈 검사에서 ⁹⁹ᵐTc-DPD의 미만성 간 섭취

Diffuse Hepatic Uptake of ⁹⁹ᵐTc-DPD on Whole Body Bone Scan: The Influence of MRI Contrast

Purpose : The whole body bone scan on nuclear medicine is a widely accepted examination and procedure. However, unusual nonosseous uptake can be observed, which reflects a rare interaction between the radiopharmacceutical and the patient. This study aimed to evaluate the influence of MRI(Magnetic Resonance Imaging) contrast and ⁹⁹ᵐTc-DPD(Dicarboxpropane diphosphonate) on whole body bone scan. Materials and Methods : We analyzed the 982 patients who were examined by ⁹⁹ᵐTc-DPD on whole body bone scan in nuclear medicine department of pusan national university hospital from january to december 2010. All these 982 patients had MRI contrast administration prior to whole body bone scan. We analyzed laboratory test. Results : 46 patients(men 39, women 7) showed diffuse hepatic uptake on whole body bone scan. These uptakes were disappeared on the follow-up whole body bone scan. There were no significant difference of CBC test, liver function tests and renal function tests. Conclusion : The study might be an indirect evidence that diffuse hepatic and splenic uptake of ⁹⁹ᵐTc-DPD on whole body bone scan after intravenous administration of Gadolinium(Gd) MRI contrast. To perform a precise examination, Gd-contrast agent should be removed from the body before performing a whole body bone scan.