방사성의약품 합성에서 발생하는 방사성기체의 효율적 차단

An Effective Block of Radioactive Gases for the Storage During the Synthesis of Radiopharmaceutical

Purpose : Methode an effective block was investigated to deal with volatile radioactive gas, short lived radioactive waste generated as a result of the routinely produced radiopharmaceuticals FDG (2-deoxy-2- [18F]fluoro-D-glucose) and compound with ¹¹C. Materials and Methods : All components of the radiation stack monitoring and data management system for continuous radioactive gas detection in the air extract system purchase from fixed noble gas monitor of Berthold company. TEDLAR gas sampling bags purchase from the Dongbanghitech company. TEDLAR gas sampling bags (volume: 10 L) connected via paraflex or PTFE tubing and Teflon 3 way stopcock. When installing TEDLAR gas sampling bags in Hot cell on the inside and not radioactive gas concentrations were compared. According to whether the Hot cell inside a activated carbon filter installed, compare the difference in concentration of the radioactive gas 18F. Comparison of radiation emission concentration difference of module a FASTlab and TRACElab. Results : Activated carbon filter are installed in the Hot cell, a measure of the concentration of radioactive gas was 8 Bq/m³. Without activated carbone filter in the hot cell was 300 Bq/m³. Tedlar bag prior to installation of the radioactive gases a measure of the concentration was 3,500 Bq/m³, ¹¹C synthesis of the measured concentration was 27,000 Bq/m³. After installed a Tedlar bag and a measure concentration of the radioactive gases was 300 Bq/m³ and ¹¹C synthesis was 1,000 Bq/m³. Conclusion : ¹¹C radioactive gas that was ejected out of the Hot cell, with the use of a Tedlar gas sampling bag stored inside. A compound of ¹¹C is not absorbed onto activated carbon filter. But can block the release out by storing in a Tedlar gas sampling bag. We was able to reduce the radiation exposure of the worker by efficient radiation protection.