방사성요오드 치료 시 완하제 투여 효과

The Effect of ¹³¹I Therapy by Taking in Laxatives

Purpose: Our goals were to evaluate the effect of high dose radioiodine treatment for thyroid cancer by taking in laxatives. Materials and Methods: Twenty patients(M:F=13:7, age 46.3±8.1 yrs) who underwent high dose radioiodine treatment were seperated into Group 1 taking ¹³¹I 5,500 MBq and Group 2 with the use of laxatives after taking ¹³¹I 5,500 MBq. The whole body was scanned 16 hours and 40 hours after taking radioactive iodines by using gamma camera, the ROIs were drawn on the gastro-intestinal tract and thigh for calculation of reduction ratio. At particular time during hospitalization, the radioactivity remaining in the body was measured in 1 meter from patient by using survey meter (RadEye-G10, Thermo Fisher Scientific, USA). Schematic presentation of an Origin 8.5.1 software was used for spatial dose rate. Statistical comparison between groups were done using independent samples t-test. P value less than 0.05 was regarded as statistically significant. Results: The reduction ratio in gastro-intestinal 16 hours and 40 hours after taking laxatives is 42.1±6.3% in Group 1 and 72.1±6.4% in Group 2. The spatial dose rate measured when discharging from hospital was 23.8±6.7 μ㏜/h in Group 1 and 8.2±2.4 μ㏜/h in Group 2. The radioactivity remaining in the body is much decreased at the patient with laxatives(P<0.05). Conclusion: The use in combination with laxatives is helpful for decreasing radioactivity remaining in the body. The radioactive contamination could be decreased at marginal individuals from patients.