비뇨기암 환자에서 ¹¹C-Acetate 양전자 방출 컴퓨터 단층 검사 (PET-CT)의 임상 적용

Clinical Application of ¹¹C-Acetate Positron Emission Tomography-Computed Tomography (PET-CT) in Patients of Urinary System Cancer

Purpose PET-CT examinations using ¹⁸F-FDG to treat urinary system cancer are limited in terms of anatomical structure and excretion route of ¹⁸F-FDG. But one of the ongoing examinations utilizing ¹¹C-Acetate can compensate for such defects. We would like to introduce a clinical application of ¹¹C-Acetate PET-CT in urinary cancer patients. Materials and Methods We conducted a clinical survey of 22 patients diagnosed with urinary cancer at our hospital, 10 prostate cancer patients, 10 renal cell carcinoma patients, and 2 bladder cancer patients. All patients were performed ¹⁸F-FDG PET-CT examinations, ¹¹C-Acetate examinations were performed after two weeks on average. The equipment used to D-710 PET-CT in GE Company and we performed PET-CT procedures 15 minutes after injecting ¹¹C-Acetate, and a medical doctor from the department of nuclear medicine appraised and compared images between ¹⁸F-FDG and ¹¹C-Acetate. Results According to our survey, prostate cancer patients generally had lower uptake of ¹⁸F-FDG than other cancer patients did. In 2 out of 10 prostate cancer patients, metastasized cancer showed greater uptake in ¹¹C-Acetate than ¹⁸F-FDG. In renal cell carcinoma cases, 8 out of 10 patients displayed evidently greater uptake in ¹¹C-Acetate than ¹⁸F-FDG. We excluded bladder cancer cases in this study because uptake of ¹⁸F-FDG in the bladder was too hot, the number of patients was insufficient, and the cases did not meet criteria such as the use of diuretics. Conclusion It is too premature to draw solid conclusions from the survey, since it involved only a small number of participants. However, there are a number of studies conducted abroad that prove the effectiveness of the ¹¹C-Acetate PET-CT examinations in treating urinary system cancer, and this study is still ongoing at our hospital. If the tests were to be conducted on a larger number of participants, this study could lead to numerous other potential research topics, such as the correlation between Prostatic specific antigen (PSA) values and ¹¹C-Acetate PET-CT, Gleason sum values from biopsy before surgery, Specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV) between ¹⁸F-FDG PET-CT examinations and ¹¹C-Acetate PET-CT examinations in other urinary system cancers.