감시림프절 검사 시 입자크기에 따른 대체 방사성의약품의 유용성평가

Evaluation on the Usefulness of Alternative Radiopharmaceutical by Particle size in Sentinel Lymphoscintigraphy

Purpose Sentinel lymphoscintigraphy (SLS) was using only ⁹⁹ᵐTc-phytate. If the supply is interrupted temporarily, there is no alternative radiopharmaceuticals. The aim of this study measure the particle size of radiopharmaceuticals and look for radiopharmaceuticals which can be substituted for ⁹⁹ᵐTc-phytate. Materials and Methods The particle size of radiopharmaceuticals were analyzed by a nano-particle analyzer. This study were selected known radiopharmaceuticals to be useful particle size for SLS. We were divided into control and experimental groups using ⁹⁹ᵐTc-DPD, ⁹⁹ᵐTc-MAG3, ⁹⁹ᵐTc-DMSA with ⁹⁹ᵐTc-phytate. For in-vivo experiment, radiopharmaceuticals were injected intradermally at both foot to perform lymphoscintigraphy. Imaging was acquired to dynamic and delayed static image and observe the inguinal lymph nodes with the naked eye. Results Particle size was measured respectively Phytate 105~255 nm (81.9%), MAG3 91~255 nm (98.7%), DPD 105~342 nm (77.3%), DMSA 164~ 342 nm (99.2%), MAA 1281~2305 nm (90.6%), DTPA 342~1106 nm (79.4%), and HDP 295~955 nm (94%). In-vivo delayed static image, inguinal lymph nodes of all experiment groups and two control groups are visible to naked eye. however, ⁹⁹ᵐTc-MAG3 of control groups is not visible to naked eye. Conclusion We were analyzed to the particle size of the radiopharmaceuticals that are used in in-vivo. Consequently, ⁹⁹ᵐTc-DPD, ⁹⁹ᵐTc-DMSA are possible in an alternative radiopharmaceuticals of emergency.