¹⁸F-Florbetaben 주사 시 Activity 손실과 통증 감소를 위한 방법

Method to Reduce the Activity Loss and Pain when Injecting ¹⁸F-Florbetaben

Purpose Neuracep is used to other diagnostic evaluations of the brain to estimate beta-amyloid neuritic plaque density in adult patients with cognitive impairment and inspected cognitive impairment. ¹⁸F-Florbetaben specially has moderate lipophilicity and property of the added ethanol. It is the subject of interest of the patient pain and residual activity after injecting. Our study is effective injection method of the radiopharmaceutical and patient care. So it is for the highest quality image. Materials and Methods Patients were targeted 70 subjects, it was injected mean 259±74 M㏃ to the patients (¹⁸F-FDG: 20 subjects,¹⁸F-FP-CIT: 20 subjects, ¹⁸F-Florbetaben: 30 subjects). After injection (reflusing 2 times, reflusing 3 times) using a 3-way set, it measured the residual activity. When injecting ¹⁸F-Florbetaben, we evaluated the effective injection methods(3-way set method and heparin cap method). The average residual activity after the injection was compared using a statistical analysis of SPSS 12.0(ANOVA, t-test analysis). Also, elemental analysis was performed on ¹⁸F-Florbetaben by GC (Gas Chromatography). Results When reflusing 2 times measured residual activity as follows (¹⁸F-FDG: 1.48 M㏃, ¹⁸F-FP-CIT: 7.4 M㏃, ¹⁸F-Florbetaben: 32.6 M㏃). And when reflusing 3 times measured residual activity as follows (¹⁸F-FDG: 1.85 M㏃, ¹⁸F-FP-CIT: 3.7 M㏃, ¹⁸F-Florbetaben: 36.3 M㏃). There was a significant difference when reflusing 2 times(P < 0.05) and reflusing 3 times (P < 0.05). But when reflusing 3 times, there was no significant difference relation FDG and FP-CIT (P > 0.05). ¹⁸F-Florbetaben Residual activity according to the injection method was a significant difference (P < 0.05). GC analysis results were measured ethanol: 207665 ppm and acceton: 377.4 ppm. Conclusion ¹⁸F-Florbetaben was high residual activity compared to FDG and FP-CIT. Heparin cap method was effective when ¹⁸F-Florbetaben was injected. ¹⁸F-Florbetaben’s ethanol component analysis was highly measured. So it is recommended that inject to 6 sec/㎖ or more in order to reduce the pain.