Febuxostat is the pH-dependent drug with low solubility in aqueous solution. In the existing method for solubilizing febuxostat, the solvent evaporation method has been widely used, but the melting method is insufficient. The aim of this study is to improve the dissolution percentage of febuxostat and stabilization through Neusilin®UFL2 and D- α-Tocopherol polyethylene glycol 1000 succinate (TPGS) ternary system using a melting method. The optimal formulation (SD1) was developed as a solid dispersion of febuxostat:UFL2®:TPGS=1:3:3 (w/w). The dissolution percentage of SD1 formulation was improved by 1.75 times (in distilled water) and 1.08 times (in pH 6.8 buffer) compared to commercial product (Feburic® tab). Moreover, changes in the physicochemical properties of febuxostat in SD1 formulation were observed (change of meting point, drug-excipients interaction and crystallinity), and it is believed that the dissolution percentage was improved through this. In conclusion, the development of a febuxostat formulation was successful through the melting method, and it is believed that the dissolution percentage was improved by the amorphous febuxostat.
서 론(Introduction)
방 법(Methods)
결과 및 고찰(Results and Discussion)
결 론(Conclusion)
감사의말씀(Acknowledgment)
Conflict of Interest
References