Purpose: The purpose of this study was to examine the effects of social support, fatigue, and depression on the quality of life of hemodialysis patients. Methods: This descriptive study included 130 hemodialysis patients treated in the artificial kidney room. The data were collected from September 20th to October 20th, 2021 and analyzed using hierarchical multiple regression analysis. Result: Social support, Fatigue, and depression were found to be significant factors affecting the quality of life of hemodialysis patients. The explanatory power of the model was 47%. Among these factors, social support (B=.36, β=.53) had the greatest impact on quality of life. Conclusion: The findings of this study indicate the necessity of developing nursing intervention programs that enhance social support and reduce fatigue and depression in hemodialysis patients, thereby improving their quality of life. Additionally, there is a need for developing tools that can quantitatively assess the effectiveness of these interventions on quality of life.
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