아크롤레인의 생체 지표인 3-Hydroxypropyl Mercapturic Acid (3-HPMA)의 소변 농도와 대사증후군과의 연관성: 국민건강영양조사 2020~2021

Association of Metabolic Syndrome with Urinary Concentration of Acrolein Biomarker 3-Hydroxypropyl Mercapturic Acid (3-HPMA): Korea National Health and Nutrition Examination Survey 2020~2021

Background: There are many published studies on the association between urinary concentration of 3-hydroxypropylmercapturic acid (3-HPMA), a metabolite of acrolein, and metabolic syndrome. However, inconsistent results have been reported. Additionally, there are currently no studies that have been conducted on Koreans. Objectives: The purpose of this study is to investigate the association between the urinary concentration of 3-HPMA, a metabolite of acrolein, and metabolic syndrome. Methods: We analyzed data from 1,559 Korean adults aged 19 and older who participated in the Korea National Health and Nutrition Examination Survey from 2020 to 2021. The criteria for metabolic syndrome were based on the National Cholesterol Education Program Adult Treatment Panel III, and the concentration of urinary 3-HPMA was divided into quartiles. The least squares means of the components of metabolic syndrome were calculated based on the concentration of 3-HPMA, and logistic regression analysis was performed to provide odds ratios (OR) and 95% confidence intervals (CI). Results: The median concentration of 3-HPMA in the participants’ urine was 420.02 (IQR: 690.51~257.30) μg/mL, and the prevalence of metabolic syndrome was 37.8%. In the comparison of quartiles, an increase in 3-HPMA concentration was associated with a higher prevalence of components of metabolic syndrome (OR: 3.05, 95% CI: 2.02~4.62). However, after adjusting for all covariates, no significant difference was found between the urinary concentration of 3-HPMA and the components of metabolic syndrome (OR: 1.38, 95% CI: 0.74~2.54). Conclusions: We did not find a significant association between the urinary concentration of 3-HPMA, a metabolite of acrolein, and metabolic syndrome.