자극 반응성 하이드로겔을 이용한 감염성 피부 창상 치료제 개발의 최신 연구 동향

Recent Advances in Stimuli-responsive Hydrogels for the Treatment of Infected Cutaneous Wounds

Stimuli-responsive hydrogels have gained much attention for the treatment of infected cutaneous wounds due to their ability to modulate drug release effectively. Under the presence of bacterial infection, drug release can be triggered by the internal or external stimuli. After bacterial removal, drug release from the hydrogels can be prevented, avoiding adverse effects on normal tissues and providing a humid condition that could help cell proliferation and tissue regeneration. Herein, we address recently published articles about stimuli-responsive hydrogels for the treatment of infected cutaneous wounds. This brief review highlights the advantages and challenges of four types of stimuli-responsive hydrogels: pHresponsive, reactive oxygen species-responsive, light-responsive, and ultrasound-responsive hydrogels. It also provides perspectives on the development of future stimuli-responsive hydrogels for the treatment of infected cutaneous wounds.