Optogenetics in the study of gustatory processing: mechanisms of taste perception and neural modulation
- 대한신경모니터링학회
- Journal of Neuromonitoring & Neurophysiology
- Vol.4 No.2
- 2024.11
- 103 - 110 (8 pages)
Optogenetics has revolutionized the ability to manipulate neuronal activity by precisely controlling light. By introducing light-sensitive proteins into specific neurons, scientists can activate or inhibit them with high temporal precision. This technique has become a powerful tool in studying the gustatory system, allowing real-time exploration of taste pathways and their effects on taste and behavior. Previous methods such as electrophysiology, neuroimaging, and genetic mapping have examined brain processes involved in gustatory processing, but they do not allow the manipulation of specific proteins or their interactions. Optogenetics offers a new approach by enabling the observation and control of neural structures and functions related to taste perception. By mapping the neural networks involved, optogenetics helps us understand the complex interactions between brain areas responsible for taste. This knowledge can potentially lead to treatments for taste disorders and strategies for taste modification, which could address conditions like aversion, obesity, and metabolic diseases. This article reviews recent advancements in optogenetics and discusses how these innovations are reshaping our understanding of taste perception and offering potential therapeutic applications.
Introduction
Basics of Optogenetics
Taste Perception Investigation through Optogenetic Modulation
Applications of Optogenetics in Taste Dysfunction Research
Current Limitations
Future Directions of Optogenetics for Taste Study
Conclusion
Funding
Conflict of Interest
Data Availavility
ORCID
References