타액의 생화학적 성분 분석과 구강 관련 요인간의 연관성 평가

The Biochemical Composition Analysis of Saliva and Evaluation of Its Association with Oral Factors

Objectives: This study aimed to analyze the correlation between saliva components, oral Candida, and oral characteristics, and to evaluate the utility of an in vitro testing device for diagnosing, preventing, treating, and educating about major oral diseases, including oral candidiasis and bad breath. Methods: In a study from May 1 to June 20, 2023, 184 female college students underwent detailed saliva analysis. Saliva samples were filtered, smeared on dextrose Sabouraud medium, cultured at 37캜 for 24 hours, and subjected to colony counting. The SiLL-Ha® saliva tester was used to analyze samples as per the manufacturer’s instructions. Participants completed questionnaires on oral characteristics, and the data were analyzed using IBM SPSS Statistics (version 22.0), with p < 0.05 considered statistically significant. Results: Participants without detectable bacteria reported higher levels of bad breath (26.98) compared to those who frequently perceived bad breath (10.83), although the ability of the device to detect only NADH restricted its correlation with bad breath. Blood perception (30.66) was linked to both periodontal disease and bad breath, while frequent dry mouth (50.76) was associated with higher white blood cell counts. Significant differences were observed in Candida bacteria, acidity, blood, protein, and ammonia levels of the participants, indicating Candida’s impact on oral health and bad breath. Conclusions: The study found significant correlations between saliva components, oral characteristics, and Candida bacteria. Findings revealed that bacterial presence and acidity influence Candida levels, elevated blood counts are linked to bad breath and poor periodontal health, and increased white blood cell counts are associated with dry mouth. The findings confirm the utility of an in vitro saliva testing device for future oral disease diagnostics and underscore its relevance in developing tools for oral health management.