Lactococcus lactis GCWB1176 (GCWB1176) is a potential probiotic supplement that can enhance human immune function. This study aimed to evaluate the function of GCWB1176 in the human immune system as a food supplement. We performed a randomized, placebo-controlled, double-blind study to ensure objective results. During the 8- week intervention period, the experimental group consumed one capsule containing 1×10¹⁰ CFU of GCWB1176 daily, whereas the control group received a placebo. Factors related to immune response, such as NK cell activity, and IFN-γ, TNF-α, IL-4, IL-10, IL-12, and WBC levels were measured. At week 4, the GCWB1176 group exhibited a significant increase in IL-12 levels and Natural killer (NK) cell activity at a 50:1 E:T (E, NK cells; T, K562 cells) ratio. However, at the endpoint week 8, no significant intergroup differences were found. The change in the intake of dietary factors such as selenium and plant fat during the experiment period apparently weakened the immunomodulatory function of GCWB1176. Nevertheless, an overall upward trend was observed in the experimental group compared with baseline. In this regard, GCWB1176 demonstrates potential for enhancing human immune function and could be developed as a dietary supplement in the future.
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