Therapeutic Effects of Theta Burst Stimulation on Cognition Following Brain Injury

This case report explores the therapeutic potential of theta burst stimulation (TBS) for cognitive enhancement in in dividuals with brain injuries. The study presents a 38-year-old male suffering from an organic mental disorder attributed to a traumatic brain injury (TBI), who demonstrated notable cognitive improvements following an intensive TBS protocol targeting the left dorsal lateral prefrontal cortex. The treatment led to significant enhancements in impulse control, irrita bility, and verbal comprehension without adverse effects. Neuropsychological assessments and brain imaging post-inter vention revealed improvements in short-term memory, abstract reasoning, list-generating fluency, and increased cerebral blood flow in the prefrontal cortex. These findings suggest that TBS, by promoting neural plasticity and reconfiguring neural networks, offers a promising avenue for cognitive rehabilitation in TBI patients. Further research is warranted to optimize TBS protocols and understand the mechanisms underlying its cognitive benefits.