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Subhealth as a Consequence of Circadian Rhythm Disruption and Insulin Resistance

The principles of yin and yang, as emphasized in traditional medical literature such as Huangdi’s Internal Classicare linked to circadian rhythm, which is essential for maintaining metabolic and functional equilibrium. Circadian rhythm disruption, which is frequently caused by chronic stress, irregular lifestyles, and circadian gene variations, can result in chronic inflammation, insulin resistance, dyshomeostasis, and a variety of chronic noncommunicable diseases including metabolic syndrome, psychiatric disorders, and cardiovascular disease. The central clock in the hypothalamus and peripheral clocks across the body work together to synchronize physiological functions with environmental cycles. However, chronic stress can disrupt the energy homeostasis maintained by the circadian rhythm, leading to metabolic dysregulation and increased disease risk. To prevent the growing prevalence of chronic noncommunicable diseases in modern society, it is essential to address circadian rhythm disruptions and insulin resistance. Traditional medicine's concept of subhealth aligns with these modern insights, as it emphasizes the importance of health preservation (yangsheng) to restore circadian rhythm and metabolic homeostasis. This approach parallels the principles of lifestyle medicine, which focuses on disease prevention and health promotion. The yin-yang and seasonal health preservation methods in traditional medicine can be reinterpreted and modernized via the lens of circadian rhythms, providing useful insights and tools for preventing and managing chronic degenerative diseases.