Osteoclast Differentiation Inhibitory Effect of Lavandula callus-derived Exosome-like Vesicles

Osteoporosis is a condition characterized by an increased risk of fracture due to decreased bone density and can develop from various causes, including menopause, aging, and inflammation. Although osteoporosis treatments such as bisphosphonates and teriparatide are currently available, they are associated with various side effects, highlighting the need for the development of safer therapeutic alternatives. Recently, exosomes derived from medicinal plants have demonstrated potential therapeutic effects in various pathological conditions, including cancer, inflammation, oxidative stress, and diabetes. Lavandula is known to possess various biological activities, including anti-inflammatory, analgesic, and wound-healing effects. Therefore, this study aimed to culture Lavandula calluses and isolate Lavandula callus-derived exosome-like vesicles to investigate their inhibitory effects on osteoclast differentiation and their anti-inflammatory properties. The results suggest that Lavandula callus derived exosome-like vesicles have potential as functional materials for improving osteoporosis and inflammatory bone loss by inhibiting osteoclast differentiation and regulating inflammatory responses.