흰쥐에서 유기인제가 식이의 변화에 따라 생체에 미치는 영향

The Effect of Parathion on Metabolism in Rats Fed Different Level of Protein and L-Ascorbic Acid

This study was designed to observe the effects of dietary protein, Ascorbic acid, glucuronolactone on growth rate, ascorbic acid contents in organs and lipid metabolism in rats fed parathion. The results of this study are summarized as follows : 1) Administration of parathion retarded the growth rate of rats. Ascorbic Acid or Glucuronolactone supplementation was found to be very effective in counteracting the growth retardation. Growth rate of the rats fed 30% casein diet was more increased than that of the 10% casein diet. 2) Hemoglobin concentration of blood and organ weights were not affected under the toxic condition by parathion administration. 3) Liver ascorbic acid contents of rats fed the diet supplemented with ascorbic acid was higher than that of other group. 4) There were no differences in serum cholesterol, triglycerides, protein level between parathion fed groups and control group. 5) Total lipid levels in liver were higher in the rats fed parathioin containing diets compared to those fed control diet. Lipid accumulation in liver was noted in the rats fed 10% Casein diet.