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Stereoselective Synthesis of (7Z, 11E)-7, 11-Hexadecadien-1-yl Acetate, Sex Pheromone of the Angoumois Grain Moth

Stereoselective Synthesis of (7Z, 11E)-7, 11-Hexadecadien-1-yl Acetate, Sex Pheromone of the Angoumois Grain Moth

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(7Z, 11E)-7, 11-Hexadecadien-1-yl acetate(1), the sex pheromone of the female Angoumois grain moth, Sitotroga cerealella, was synthesized via the acetylenic intermediate, (11E)-11-hexadecen-7-yn-ol THP ether(2). The acetylenic compound was prepared from 7-octyn-1-ol THP ether(4) and (3E)-1-bromo-3-octene(3). The (E)-homoallylic bromide 3 was synthesized by the Julia olefin synthesis of 1-cyclopropylpentan-1-ol(6).

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