Ruthenium Complex Catalyzed Syntehesis of Diamino Compounds from ${\alpha},{\omega}$-Diols and Secondary Amines

Ruthenium Complex Catalyzed Syntehesis of Diamino Compounds from ${\alpha},{\omega}$-Diols and Secondary Amines

${\alpha},{\omega}$-Diols react with secondary amines in the presence of a catalytic amount of ruthenium catalyst at $180^{\circ}C$ to give diamino compounds in good to excellent yields. The yield of diamino compound was affected by the molar ratio of ${\alpha},{\omega}$-diol to secondary amine. The reaction is affected by the nature of the phosphorus ligands employed and the effectiveness of the added ligand is completely different depending on the chain length of the ${\alpha},{\omega}$-diol. The reaction between ethylene glycol and primary amine in the presence of a catalytic amount of ruthenium catalyst gave 1,4-disubstituted piperazine.